Livestock infections don’t merely harm single animals—they imperil the health, productivity, and economic sustainability of the whole herd. From fever and mastitis to respiratory and intestinal disease, swift action is essential in large and small ruminants.
Oxytetracycline Hydrochloride bolus provides broad-spectrum antibacterial activity—but its effectiveness in the field is based on more than one drug class. In actual use in veterinary medicine, bolus disintegration rate, stability in the gut, and absorption at the tissue level may mean success or failure for an animal.
Therawin Formulations produces Oxytetracycline bolus with veterinary pharmacodynamics in mind:
- Controlled disintegration to maximise gut absorption and minimise rumen degradation
- Constant plasma levels to provide an extended antibacterial effect
- Improved tissue distribution to effectively target respiratory, gastrointestinal, and mammary locations
This bolus is one aspect of a larger mission—to enable therapeutic predictability under field conditions. And that’s where Therawin Formulations differentiates: with veterinary-targeted drug delivery systems that synchronise with real-time infection patterns.
Looking for a trustworthy Oxytetracycline bolus manufacturer in India? Partner with Therawin Formulations—a WHO-GMP & ISO-certified veterinary producer of pharma PCD franchise and third-party pharma manufacturing collaborations for infection control products in animal care.
Generic name
Oxytetracycline Hydrochloride 500 mg
Pack
8 x 4 Strip
Description
Every bolus contains 500 mg of Oxytetracycline Hydrochloride, a tetracycline-class broad-spectrum antibiotic. Oral use in animals is intended and delivers consistent protection from a wide spectrum of bacterial pathogens and atypical bacteria like Mycoplasma, Chlamydia, and Rickettsia.
Oxytetracycline interferes with the growth and multiplication of susceptible bacteria, thus inhibiting aminoacyl-tRNA from attaching to the mRNA-ribosome complex. This results in:
- Protein synthesis inhibition, arresting bacterial growth and replication
- Halt in the progress of infection, giving the animal’s immune system an opportunity to take over
- Bacterial load reduction, resulting in progressive relief of symptoms and clinical improvement
Its broad spectrum activity makes it indicated for treating mixed infections or when the causative organism has yet to be known. Employed properly, Oxytetracycline promotes recovery, cuts down disease spread, and enhances productivity in infected animals.
Oxytetracycline bolus uses
Oxytetracycline bolus is a once-daily broad-spectrum oral antibiotic used in the treatment of bacterial diseases of large and small ruminants. It is particularly beneficial in the treatment of herd-level infection where systemic antibiotic support is essential.
Which infections does it target?
- For cattle and buffaloes: Mastitis, metritis, anaplasmosis, respiratory tract infections, and wound infections. (Administer 2–4 boluses per day based on weight and severity. Use a bolus gun to ensure the bolus reaches past the tongue—if chewed or spit, antibiotic coverage may be incomplete. Maintain a consistent 24-hour interval between doses unless advised otherwise.)
- For goats and sheep: Foot rot, pneumonia, and bacterial infections post-lambing. (Use ½ to 1 bolus per day, depending on weight. For light sheep or goats, veterinary advice is essential—incorrect dosing can cause resistance or relapse. Always give bolus whole—crushing can decrease effectiveness and enhance bitterness.)
- For uterine post-calving infection: Assists with the treatment of endometritis or infected retained placental disease in cows. (Must be combined with supportive therapy such as hydration and dietary management. Refrain from using during the initial stages of pregnancy unless indicated by a vet.)
In poultry areas (indicational, not direct use): When oxytetracycline is given through water solubles, the bolus can be included as part of an overall farm-level treatment program for large ruminants at risk for the same pathogens.
Prevent the use of the bolus in animals with hypersensitivity to tetracyclines. Provide access to clean water for drinking during treatment, as dehydration can exacerbate infection results and hinder absorption.
Oxytetracycline bolus side effects
Oxytetracycline bolus finds extensive application for the treatment of systemic and respiratory infections, wound infection, and mastitis in big animals. Although effective, misuse or inability to follow withdrawal times may contribute to complications with far-reaching effects on animal well-being and farm efficiency.
Mild & temporary reactions
(Generally manageable and short-term)
- Decreased appetite – A frequent side effect of antibiotic treatment. Provide the animal with fresh, palatable food and clean water to avoid energy loss.
- Loose stool or gut imbalance – Oxytetracycline can upset beneficial gut bacteria, particularly with prolonged usage. Support with probiotics or provide fibre-rich feed after treatment to regain balance.
- Photosensitivity – Light-colored or short-haired animals can get sunburn-like rashes following exposure outdoors. Offer shade or stable rest during and immediately after treatment.
Serious or regulatory-sensitive concerns
(Requires action to prevent long-term consequences)
- Residue concerns in milk and meat
- Milk withdrawal – Dispose of milk for a minimum of 72 hours following the last dose to avoid antibiotic residues.
- Meat withdrawal – Do not send animals to slaughter until 7 days after treatment to allow for food safety compliance.
- Risk in early pregnancy – Do not use in animals during the first trimester, as tetracyclines have the potential to interfere with fetal bone formation or cause resorption.
- Drug interaction – Do not mix with calcium, magnesium, or aluminium-containing supplements or antacids—these will bind the drug and decrease its absorption. Space doses at least 1–2 hours if co-administered.
Common mistakes to avoid:
- Missing the full course of treatment – Incomplete dosing can leave infection behind, leading to relapse and antibiotic resistance.
- Underdosing in ruminants – Bolus size should be proportional to body weight. Underdosing decreases effectiveness and promotes resistance.
- Ignoring hydration – Oxytetracycline is renally excreted; dehydration enhances the risk of nephrotoxicity. Ensure optimal fluid intake throughout therapy.
How to store Oxytetracycline bolus?
- Avoid humid environments like barns or feed sheds: Oxytetracycline is highly moisture-sensitive. Exposure to damp air or condensation can trigger early degradation, weakening its antibacterial activity—especially against resistant respiratory or enteric pathogens.
- Keep away from mineral supplements or medicated blocks: The bolus may absorb residual odors or volatile compounds from nearby substances. This not only affects the potency but may also alter the rate of disintegration once administered.
- Do not store above 30°C or under direct sunlight: Excessive heat causes chemical instability, leading to discoloration and reduced shelf-life. In some cases, heat-altered oxytetracycline may irritate the gastrointestinal lining or lose its extended-release property.
Oxytetracycline bolus manufacturer and supplier in India
In large-animal care, Oxytetracycline is often the first line of defence against systemic and respiratory bacterial infections. But for veterinary distributors, the concern isn’t just potency—it’s consistency across cases, seasons, and animal classes.
That’s where most generic suppliers underdeliver.
At Therawin Formulations, we manufacture field-grade Oxytetracycline bolus engineered for broad-spectrum bacterial control in ruminants and working animals. With over 35 years in livestock pharma, we’ve helped distributors address critical gaps in:
- Delayed bacterial response due to slow-release errors
- Breakdowns in packaging under monsoon or storage stress
- A mismatch between dose strength and livestock category
Our bolus line solves these risks through:
- Standardised 500 mg and 1000 mg variants – Optimized for both large and medium ruminants
- Controlled disintegration profile – Ensures rapid bloodstream absorption without gastric disruption
- Foil-blistered packs – Withstand humid, rural, or warehouse conditions
- Bulk readiness – Structured for fast-moving veterinary networks and institutional supply orders
- Custom private labelling – Supporting third-party pharma manufacturers and regional pharma PCD franchise expansions
If you’re building a veterinary antibiotic portfolio, managing district-level procurement, or seeking a stable Oxytetracycline manufacturer with consistent batch supply—Therawin helps you meet demand with clinical-grade confidence.
Available in customisable packaging for pharma PCD franchise distributors, third-party pharma manufacturing, and franchise owners. Reach out for commercial terms, sample packs, or partnership onboarding.