Coccidiosis, bacterial enteritis, and respiratory infections are more than temporary disruptions in livestock—they compromise nutrient absorption, suppress growth, and elevate treatment costs when not addressed promptly. For veterinarians and field workers, early intervention with a targeted antimicrobial becomes crucial—especially in weak or dehydrated animals.
Sulphadimidine bolus delivers broad-spectrum sulphonamide therapy for protozoal and bacterial infections in cattle, buffaloes, sheep, and goats. With rapid systemic absorption and flexible strength options (0.5 g and 5 g), it supports weight-adjusted dosing and helps restore feed intake and hydration—critical during early-stage disease progression.
But therapeutic outcomes aren’t determined by active ingredients alone. Effective antimicrobial intervention depends on:
- Controlled particle sizing for consistent bioavailability
- Reliable disintegration to ensure timely absorption—even in compromised animals
- Uniform therapeutic range tailored for species-specific dosing protocols
This bolus is part of a larger commitment—to ensure dependable treatment response in field conditions where time, accuracy, and resilience matter. And that’s where Therawin Formulations brings its precision: as a WHO-GMP and ISO-certified veterinary manufacturer focused on pharmacokineticsl consistency and real-world efficacy.
Looking for a Sulphadimidine bolus manufacturer in India? Therawin Formulations supports veterinary PCD franchises and third-party manufacturing with sulphonamide therapies engineered for clinical reliability and practical use across livestock health programs.
Generic name
Sulphadimidine 5 gm / 0.5 gm
Pack
10 x 4 Blister
Description
Sulphadimidine, also known as sulfamethazine, is a broad-spectrum sulfonamide antibiotic formulated to treat respiratory, gastrointestinal, and certain protozoal infections in animals. It is available in:
- 5g bolus – intended for use in large ruminants such as cattle and buffaloes
- 0.5g bolus – suitable for small ruminants, including sheep and goats, and for administration in poultry
Sulphadimidine acts by interfering with the synthesis of folic acid in susceptible organisms. It competitively inhibits dihydropteroate synthase, an enzyme crucial to the production of folic acid, which bacteria and protozoa need to replicate. This disruption leads to:
- Inhibited DNA synthesis, preventing cell division
- Arrested growth of bacterial and protozoal populations
- Gradual clearance of infection as the animal’s immune system regains control
By targeting the metabolic machinery essential for microbial replication, Sulphadimidine ensures a controlled reduction of infection, supporting faster recovery and minimising the spread within herds or flocks.
Sulphadimidine bolus uses
Sulphadimidine bolus is an oral sulfonamide antimicrobial used for early control of systemic and intestinal bacterial infections in livestock. It works by interfering with folic acid synthesis, stopping bacterial growth at the root level.
Which infections does it target?
- For cattle and buffaloes: Respiratory tract infections, early-stage toxaemia, and septic fever. (Use a bolus gun for accurate throat placement. Ruminants may resist swallowing—restrain the head and observe until the bolus is fully ingested. Re-dose only under veterinary direction to avoid overdosing.)
- For sheep and goats: Coccidiosis, bacterial diarrhea, and weakness caused by enteric infections. (Use a small ruminant applicator. Do not crush the bolus—it causes bitter feed aversion and dosing errors. Dosage varies based on weight; refer to standard sheep/goat treatment charts.)
- For poultry: Coccidial outbreaks in young flocks, especially under crowded or wet conditions. (This bolus is not administered whole to poultry. Instead, it is typically dissolved and mixed into drinking water. Always consult a vet to calculate the flock-wide dosing volume and ensure complete consumption.)
Never give to non-target or sulfonamides sensitive animals.Their metabolic pathways differ and may not tolerate sulfonamides safely.
Avoid unsupervised re-dosing. Sulphadimidine requires careful weight-based adjustment to prevent crystalluria and kidney strain—especially in dehydrated animals.
Sulphadimidine bolus side effect
Sulphadimidine is a commonly used sulfonamide antibiotic in animals, particularly for the treatment of bacterial infections such as coccidiosis and respiratory diseases. Though effective and quite well-tolerated, inappropriate dosing, excessive use, or species-specific sensitivities may result in preventable complications.
Mild & temporary reactions
(Usually self-resolving when monitored)
- Crystalluria (urinary crystals) – Sulphonamides precipitate in urine if hydration is inadequate. Ensure access to clean drinking water both during and after therapy to avoid renal stress.
- Decreased feed intake – Transitory fall in appetite caused by systemic antibiotic effect. Monitor the intake and provide fresh, palatable feed to return feeding to normal.
- Mild rashes or hives on the skin – Uncommon but can occur through hypersensitivity; usually mild and disappears after withdrawal.
Rare & serious side effects
(Stop administration and consult a vet if observed)
- Signs of kidney dysfunction – In animals with existing renal dysfunction, sulfonamides can increase toxicity. Observe for dark urine, decreased urination, or indications of distress—immediately seek veterinary consultation.
- Anaphylaxis (rare) – If you notice difficulty breathing, swelling, or collapse, treat it as a medical emergency and get urgent treatment.
Common mistakes to avoid:
- Missing hydration – Always keep animals well-hydrated prior to and during therapy. Dehydration heightens crystalluria risk.
- Incomplete course – Even if improvement is seen early, premature cessation of treatment may result in relapse and antimicrobial resistance. Complete the full recommended course.
- In lactating or pregnant animals without supervision – Avoid late gestation and high milk production unless specially instructed. Sulfonamide residues can compromise milk safety as well as fetal health.
- Other nephrotoxic drugs in combination – Avoid concomitant use with other kidney-stressing drugs unless supervised professionally.
How to store Sulphadimidine bolus?
- Keep the bolus below 30°C—especially in humid zones: Prolonged exposure to heat or fluctuating temperatures can lead to slow hydrolysis of the sulfonamide compound. This reduces its antibacterial potency, making it less effective against systemic infections like coccidiosis or salmonellosis.
- Avoid exposure to UV rays and direct sunshine: Sulphadimidine is light-sensitive. UV exposure may accelerate molecular breakdown, causing early loss of therapeutic activity—especially in bolus stored outside blister packs.
- Check each bolus for color fading or cracks before use: Discoloration or physical damage may indicate oxidative degradation or age-related loss of stability, both of which affect bioavailability and uniform dosing.
Sulphadimidine bolus manufacture and supplier in India
For livestock distributors, Sulphadimidine is a first-response antibiotic—often stocked ahead of seasonal surges in coccidiosis, pasteurellosis, and bacterial scours. In many regions, inconsistent formulation strength and short shelf lives have made restocking this essential product a risk.
Therawin Formulations bridges that reliability gap.
With over 35 years in veterinary manufacturing, we’ve tailored our Sulphadimidine Bolus to meet the real-world needs of pharma PCD franchise distributors and rural stockists who can’t afford product failures in critical conditions.
Here’s how we make it work:
- High-potency Sulphadimidine – Backed by batch-tested purity and solubility for faster absorption in stressed animals
- Built for both cattle and small ruminants – Weight-based boluses with stable shelf life, even in humid zones
- GMP-certified production with ISO-aligned traceability – Satisfying both regulatory audits and export demands
- Support for veterinary franchises and third-party manufacturing – From foil-sealed packs to custom regional branding
- Consistent supply calendar – For distributors building livestock medicine portfolios around predictable field usage
Veterinarians depend on this bolus for acute infections, post-transport fever spikes, and diarrhoea linked to gut bacteria. For your business, that translates into sustained field demand—delivered through our Pharma PCD franchise distribution support or as part of our third-party pharma manufacturing service.