Gastrointestinal infections in livestock demand more than symptomatic relief. Bacterial diarrhoea and protozoal dysentery lead to dehydration, poor nutrient absorption, and rapid weight loss—directly impacting milk yield, feed efficiency, and herd health.
That’s why the Metronidazole + Furazolidone + Loperamide bolus is engineered as a three-pronged intervention:
- Metronidazole targets protozoa and anaerobic bacteria,
- Furazolidone broadens the antimicrobial spectrum,
- Loperamide reduces gut motility, minimising fluid loss.
But therapeutic effectiveness in ruminants hinges on more than active ingredients—it requires:
- Dose uniformity and bolus disintegration matched to ruminant digestion
- Sustained drug release for extended intestinal exposure
- Tolerability and absorption under compromised gut function
This bolus is developed as part of a broader veterinary strategy—to manage infectious diarrhoea in a way that supports clinical recovery without compromising performance metrics. Therawin Formulations manufactures under WHO-GMP and ISO-certified systems, ensuring pharmaceutical-grade quality for veterinary use.
Looking for a Metronidazole + Furazolidone + Loperamide Bolus manufacturer in India? Therawin Formulations supports third-party pharma veterinary manufacturing and pharma PCD franchise opportunities—built on scientific formulation, field-oriented design, and regulatory compliance.
Generic name
Metronidazole 1000mg + Furazolidone 200 mg / 500mg + Loperamide 4 mg / 7.5 mg
Pack
10 x 4 Blister
Description
This gastrointestinal (GI) support bolus is formulated with three active agents that target infectious diarrhea, protozoal infections, and motility imbalance in animals. Each bolus delivers:
- Metronidazole (1000 mg) – An antiprotozoal and antimicrobial compound effective against Giardia, Entamoeba, and anaerobic bacteria commonly implicated in enteric infections.
- Furazolidone (200/500 mg) – A broad-spectrum nitrofuran derivative that disrupts gram-negative and gram-positive bacteria, especially those found in unhygienic water or contaminated feed.
- Loperamide (4/7.5 mg) – A peripherally acting μ-opioid receptor agonist that slows intestinal motility, allowing more time for fluid and electrolyte absorption in the gut.
Together, these actions result in:
- Reduction in stool frequency and fluidity
- Elimination of infectious organisms causing diarrhea and dysentery
- Support for digestive recovery and hydration balance, especially in animals exposed to poor sanitation or contaminated feed sources.
Metronidazole + Furazolidone + Loperamide bolus
This combination bolus is an oral antidiarrheal designed to manage gastrointestinal infections caused by bacteria and protozoa in field livestock. It reduces gut inflammation, controls watery stools, and restores intestinal balance during stress or infection outbreaks.
Which infections does it target?
- For cattle and buffaloes: Bacterial enteritis, protozoal dysentery, and waterborne diarrhea. (Use a large-animal bolus gun to deliver the bolus past the tongue. If improperly administered, animals may chew or spit it out, affecting absorption. Ensure clean hands/gloves are used to prevent contamination.)
- For goats and sheep: Mild to moderate bacterial diarrhea caused by contaminated grazing or feed changes. (Use a small-ruminant bolus applicator. Never attempt to crush and hide in feed—the bitter aftertaste often leads to rejection. Administer gently while restraining the head.)
- For field livestock during monsoon or transport: Diarrhea triggered by muddy water, sudden climate change, or stress-related gut imbalances. (Give during early symptoms—delaying treatment may lead to dehydration. Rehydration support should accompany the bolus in severe cases.)
Use only under veterinary supervision, especially when used as a follow-up after antibiotics or for herd-wide gut health support.
Metronidazole + Furazolidone + Loperamide bolus side effects
This combination bolus is commonly used to manage bacterial and protozoal infections with diarrheal symptoms in large animals. When used correctly, it’s generally well-tolerated. But misuse, overuse, or individual animal sensitivity can lead to adverse effects—some mild, others requiring immediate care.
Mild & temporary reactions
(Often short-lived and self-resolving)
- Constipation – Loperamide slows intestinal movement. A temporary reduction in bowel frequency may occur. Offer fibre-rich feed or bran mash to stimulate gut motility.
- Reduced feed intake – Some animals may lose appetite during treatment. Ensure access to clean water and palatable fodder to maintain hydration and energy levels.
- Mild salivation or drooling – Often due to the bitter taste of Metronidazole or Furazolidone. No treatment is necessary; it fades within minutes.
Rare & serious side effects
(Call a veterinarian immediately if these occur)
- Neurological signs in young or debilitated animals – Overdosing on Metronidazole may trigger tremors, unsteady gait, or head-tilting. These indicate central nervous system involvement. Stop treatment and contact your vet.
- Allergic responses – Look out for sudden swelling, hives, laboured breathing, or collapse. These may be signs of drug hypersensitivity—considered an emergency.
- Severe dehydration – Loperamide may excessively slow intestinal flow in animals already dehydrated, worsening absorption issues. Administer oral or IV fluids as advised by a vet.
Common mistakes to avoid:
- Furazolidone may impact fetal development, therefore avoid using it in pregnant or nursing animals unless specifically authorized by a veterinarian.
- Never exceed the recommended duration (usually 3–5 days) – Prolonged exposure increases the risk of neurological toxicity or liver enzyme elevation.
- Do not administer in severely dehydrated animals – Always stabilise with fluids first; otherwise, Loperamide may exacerbate toxic buildup.
How to store Metronidazole + Furazolidone + Loperamide bolus?
- Avoid refrigeration or damp storage rooms: All three components—Metronidazole, Furazolidone, and Loperamide—are susceptible to moisture-induced degradation. Refrigerators can increase humidity exposure, leading to slow breakdown of active ingredients and reduced shelf-life.
- Keep in original blister packaging until immediate use: The bolus is moisture-sensitive. Unblistered exposure allows humidity to enter the porous matrix, potentially altering disintegration time during administration and impacting gastrointestinal release.
- Do not store near animal feed sacks or supplements: The bolus may absorb feed-related odors or fine particles that alter its outer coating or make animals reject the dose when administered.
Metronidazole + Furazolidone + Loperamide bolus manufacturer and supplier in India
When livestock owners face acute diarrhea cases, they don’t wait—they demand the fastest-acting GI bolus you have in stock. And if your formulation underdelivers, you don’t just lose a sale—you lose trust.
That’s why veterinary distributors and animal health franchises choose Therawin Formulations—a manufacturer trusted to deliver reliable gut recovery within 24 hours of administration.
With 35+ years of veterinary R&D, we manufacture this triple-action GI bolus with:
- Synergistic anti-diarrheal ratio – Targeting bacterial, protozoal, and toxin-induced gut imbalance
- Veterinary-grade compression & binding – Ensures full bolus intake even in weak or stressed animals
- Livestock-specific strengths – No guesswork, no need to break or modify doses
- Stable performance in high-humidity zones – Backed by validated shelf-life & absorption studies
- PCD-ready infrastructure – With private-label support, MOQ flexibility & on-time dispatches
Whether you’re managing bulk supply in high-yield dairy belts or expanding veterinary franchise operations, Therawin’s GI recovery line ensures consistent results and sustained demand. As an ISO-certified veterinary manufacturer, we bring quality assurance to every bolus—validated across absorption, stability, and field performance.
Partner with Therawin Formulations for Pharma PCD franchise distribution or third-party manufacturing of Metronidazole + Furazolidone + Loperamide Bolus—a clinically developed combination trusted for rapid gut restoration and ready supply support.