Internal parasites don’t just affect animal health—they reduce nutrient absorption, slow weight gain, and cause silent economic losses. Skin mites and blood-feeding pests add another layer of damage. In large ruminants, early and effective intervention matters.
That’s where Ivermectin bolus delivers value. With a single oral dose, it offers broad-spectrum coverage against gastrointestinal worms, lungworms, lice, mites, and other ectoparasites—ensuring extended parasite control with minimal handling stress.
At Therawin Formulations, bolus design is guided by pharmacokinetics and field efficacy—not generic specifications. Each unit is engineered with:
- Controlled disintegration to support uniform systemic absorption
- Stabilized Ivermectin content for sustained plasma levels
- Dose architecture tailored to ruminant GI physiology
This bolus is part of a broader therapeutic approach—to support parasite control programs that are both evidence-based and practical for field implementation. And that’s where Therawin Formulations focuses its capabilities: developing veterinary formulations that meet clinical performance standards under real-world conditions.
Looking for an Ivermectin bolus manufacturer in India? Therawin Formulations supports pharma PCD franchise and third-party pharma veterinary manufacturing with a focus on consistency, bioavailability, and compliance—under WHO-GMP and ISO-certified systems.
Generic name
Ivermectin 80 mg
Pack
20 x 1 Blister
Description
Ivermectin bolus is a broad-spectrum endectocide formulated for the treatment and control of both internal and external parasites in large animals. Each bolus delivers a calibrated dose of 80 mg of Ivermectin, making it suitable for use in adult cattle and buffalo. Its systemic action targets nematodes, arthropods, and migrating larvae, supporting effective parasite management across production cycles.
Ivermectin belongs to the macrocyclic lactone group (avermectins) and acts against:
- Gastrointestinal and pulmonary nematodes (e.g., Haemonchus, Ostertagia, Dictyocaulus)
- Blood-feeding ectoparasites (e.g., lice, mites, mange-causing species)
- Larval stages of migrating parasites
Ivermectin primarily binds to glutamate-gated chloride channels in the parasite’s muscle and nerve cells. This action leads to:
- Increased chloride ion influx, disrupting neurotransmission
- Flaccid paralysis of the parasite, preventing feeding and attachment
- Gradual death and elimination through natural physiological processes
Its high affinity for parasite neural tissue, paired with minimal activity in mammals, ensures safety for the host while achieving comprehensive parasite control in herd animals.
Ivermectin bolus uses
Ivermectin bolus is an oral antiparasitic designed for broad-spectrum internal and external parasite control in grazing and farm livestock. It’s typically administered as a single dose and plays a critical role in seasonal parasite management programs.
Which parasites does it target?
- For cattle and buffaloes: Gastrointestinal roundworms (e.g., Haemonchus, Ostertagia, Trichostrongylus) and lungworms (Dictyocaulus). (Use a standard bolus gun to deliver deep into the esophagus. Do not administer to fasting animals—proper nutrition ensures optimal absorption of the lipophilic drug.)
- For goats and sheep: Mange mites (Sarcoptes, Psoroptes), biting lice, and nasal bots. (Use a small-ruminant applicator. If animals resist, restrain calmly—partial bolus dosing may be required based on weight. Do not crush or mix with feed—the compound may lose its slow-release efficacy.)
- For high-yielding livestock during tick seasons: Helps reduce tick infestation levels, thereby lowering the risk of tick-borne stress and improving milk/meat output. (Administer at the onset of monsoon or when tick pressure is highest. Follow up with environmental control measures for sustained results.)
- For control of grub in cattle: Active against Hypoderma larvae, minimising hide damage and systemic allergic responses. (Treat during the initial larval migration stage—late treatment can cause undesirable reactions from dead larvae.)
Do not use in lactating dairy animals unless specifically cleared by your veterinarian.
Precautions against use within 14 days of and following vaccination—immune interference possible. Keep out of reach of dogs, cats, or equines—the risk of ivermectin toxicity is great in non-target species.
Ivermectin bolus side effects
Ivermectin bolus is a very powerful antiparasitic used extensively for the treatment of internal and external parasites in cattle, buffaloes, and large ruminants. Although generally safe when given in recommended dosages, some reactions can occur—particularly in young, underweight, or heavily parasitised animals.
Mild & temporary reactions
(Common, self-limiting effects)
- Salivation or slobbering – This may be seen a short while after dosing with taste sensitivity. No treatment is required unless profuse.
- Loose stools or slight diarrhea – With the expulsion of internal parasites comes digestive upset. Watch for dehydration and give light, fibre-free rations.
- Lethargy or decreased feed intake – Certain animals exhibit dull behaviour for 12–24 hours after treatment. Provide clean water and rest; symptoms will often resolve on their own.
Rare & serious reactions
(Require prompt veterinary attention)
- Neurotoxicity symptoms – Overdosage or sensitivity may result in tremors, loss of coordination, or collapse, especially in young calves or stressed animals. Stop treatment immediately and seek a veterinarian.
- Skin sensitivity or swelling – In heavily parasitised animals, sudden die-offs can cause allergic responses like itchiness, bumps, or hives. Administering antihistamines or supportive therapy is recommended.
- Laboured breathing or seizures – Very rare, but may occur in heavily overdosed or immunocompromised animals. Emergency treatment is needed.
Common mistakes to avoid:
- Do not give in animals below the minimum weight range – Overdosing is more likely in underweight calves or skinny livestock.
- Avoid use in lactating animals that yield milk intended for human consumption unless a rigorous withdrawal time is observed—according to veterinary advice.
- Don’t re-dose too early – Ivermectin possesses a prolonged half-life. Repeating the dose too early enhances the potential for toxic accumulation in the animal.
- Avoid using drugs that interfere with the nervous system – This can enhance neurotoxicity.
How to store Ivermectin bolus?
- Avoid exposure to direct sunlight or barn heat: Ivermectin is photosensitive. Prolonged light or heat exposure may degrade its chemical structure, reducing its efficacy—especially in cases of stubborn parasitic infections like Haemonchus or Ostertagia.
- Never refrigerate or freeze the bolus: Ivermectin formulations are moisture-sensitive. Cold storage can cause condensation once brought back to room temperature, leading to surface softening, disintegration, or uneven dosing.
- Keep in original blister packaging until use: The protective seal prevents oxidation and shields the bolus from environmental humidity. Removing the bolus prematurely may compromise the stability of the active ingredient.
- Store away from animal feed and mineral supplements: Ivermectin can absorb strong odors or airborne dust from nearby feed, potentially altering its palatability. Some animals may reject the dose if the bolus carries off-flavours or appears altered.
Ivermectin bolus manufacturer and supplier in India
Many veterinary distributors know the real issue isn’t a shortage of the Ivermectin bolus. It’s the unpredictability that some batches work. Some don’t. And when they don’t, it’s not just parasite survival—it’s loss of milk yield, weight stagnation, and farm trust.
That’s the hidden cost of inconsistent formulations, weak content uniformity, and no traceability.
That’s where Therawin Formulations make the difference.
With over 35 years in veterinary manufacturing, we offer a bolus that’s not just compliant—but reliable at scale:
- Standardised 80 mg Ivermectin dose – For consistent deworming results in cattle, buffaloes, and large ruminants
- WHO-GMP-certified production – Meeting the requirements of government tenders and private-sector audits
- Batch-to-batch content uniformity – Reducing the chances of treatment failure or under-dosing
- Bulk supply readiness – For livestock departments, institutional orders, and seasonal demand peaks
- PCD franchise and private labelling support – Helping you build a trusted name in your territory
Whether you handle procurement for a regional franchise or supply dewormers to veterinary hospitals and farms, you need a manufacturer that removes uncertainty.
Contact Therawin Formulations today for bulk orders, pharma PCD franchise partnerships, or custom-label third-party pharma manufacturing options tailored to your region.