When a dairy cow doesn’t come back into estrus, it’s not a missed cycle—it’s a month of lost milk production, delayed calving, and increasing costs per conception. Silent heat, anestrus, and ovarian quiescence demand more than normal care—they require a focused reproductive reboot.
That’s where the Clomiphene Citrate + Copper Sulphate bolus comes in—triggering ovulation while balancing trace mineral deficiencies that tend to inhibit the hormonal response. The outcome? A well-timed, well-regulated heat cycle with enhanced odds of conception.
But the efficacy of the formula isn’t necessarily in what it does—it’s in how it performs under actual farm conditions:
- Time-synchronized ovulation stimulation that simulates natural hormonal cycles
- Bioavailable copper to enhance ovarian responsiveness
- A metabolism-aligned matrix constructed for ruminant absorption and retention
This bolus is part of a strategic therapeutic strategy—designed to minimise reproductive anomalies through both endocrine stimulation and micronutrient correction. Our concern at Therawin Formulations is not generic product assertions but precision-designed veterinary formulations aligned with on-field reproductive protocols and species-specific physiological requirements.
As WHO-GMP and ISO-certified manufacturer, we formulate products where product integrity intersects with measurable results. Searching for a Clomiphene Citrate + Copper Sulphate bolus manufacturer in India who knows the value of a missed cycle?
Join Therawin—we facilitate livestock care with third-party pharma manufacturing and pharma PCD franchise options, making your veterinary supply deliver what farms need most: reproductive reliability, cycle after cycle.
Generic name
Clomiphene Citrate 300 mg + Copper Sulphate 1500 mg
Pack
5 x 1 Blister
Description
This fertility-support bolus provides two-way support by addressing both hormonal control and mineral balance critical to reproductive performance in livestock. Each bolus has:
- Clomiphene Citrate (300 mg) — a selective estrogen receptor modulator (SERM)
- Copper Sulphate (1500 mg) — a trace mineral supplement
Clomiphene Citrate works at the hypothalamic-pituitary axis by antagonising estrogen receptors, which results in:
- Augmented secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH)
- Stimulation of follicular growth and triggering of ovulation
- Restitution of normal estrous cycles in instances of anestrus or silent heat
Copper Sulphate targets trace mineral imbalances prevalent in pasture systems, where copper is likely to be low. It acts in:
- Aiding enzymatic pathways crucial for hormone metabolism
- Improving ovarian responsiveness and uterine tone
- Stimulating general reproductive tissue well-being and functioning
All these elements function synergistically to restore ovarian function, restore cyclicity, and enhance the success of breeding results.
Clomiphene + Copper bolus uses
This oral fertility bolus is designed to stimulate ovulation and correct estrus irregularities in large ruminants. It supports hormonal balance and trace mineral replenishment, helping animals return to a fertile cycle—especially after calving or reproductive setbacks.
When should it be used?
- For cows and buffaloes:
- Anestrus: No visible signs of heat even after 60–90 days postpartum
- Silent heat: Ovulation occurs, but no behavioral signs are detected
- Repeat breeding syndrome: Failure to conceive despite 3+ insemination.
(Administer using a large bolus gun. Give as a single dose 5–7 days before scheduled insemination. Avoid handling stress or rough restraint during dosing—it may reduce hormonal response.)
- For high-yielding dairy cattle under fertility programs:
- Enhances conception rates during artificial insemination (AI) or embryo transfer
- Supports hormone synchronisation in herd breeding protocols
(Should be used in planned cycles monitored by veterinarians or livestock technicians. Combine with rectal palpation or heat detection aids to ensure timing accuracy.)
Do not use in small ruminants or equines—the hormonal action and bolus size are unsuitable. Off-label use can lead to reproductive disruption or overdose symptoms.
Clomiphene initiates ovulatory signaling, while copper supports uterine recovery and mineral balance. For best results, track the animal’s heat history and pair it with adequate nutrition and mineral supplementation. Avoid giving alongside other hormone injections unless prescribed.
Clomiphene + Copper bolus side effects
This bolus is formulated to support estrus induction and optimise conception rates in anestrus and sub-fertile livestock. While safe under veterinary guidance, misuse can lead to hormonal or mineral-related complications.
Mild & temporary reactions
(Generally non-serious and short-lived)
- Restlessness or mounting behavior – Clomiphene triggers hormonal activity that may cause temporary agitation or over-eagerness in herd animals. This is expected as part of heat expression and typically subsides within a day.
- Appetite fluctuation – Some animals may exhibit a mild drop in feed intake post-administration, particularly when hormonal shifts begin. Ensure routine feeding continues uninterrupted.
- Discomfort at high copper doses – If the animal has recently received injectable copper or high-copper feed, the bolus may cause nausea or loose stools.
Serious reactions & risks
(Veterinary consultation is advised if these appear)
- Copper toxicity – Excessive copper accumulation (especially in sheep or copper-sensitive breeds) may present as lethargy, yellow mucous membranes (jaundice), or dark-coloured urine. Immediate veterinary attention is critical.
- Hormonal imbalance – Improper timing or repeated Clomiphene dosing without a proper breeding protocol can lead to cystic ovaries or delayed ovulation cycles, especially in buffaloes or hormonally stressed animals.
- Accidental use in pregnant animals – This may interfere with gestation and lead to early termination or embryonic loss.
Common mistakes to avoid:
- Avoid copper overlap – Check current mineral intake (blocks, injectables, premixes) to ensure you’re not exceeding copper tolerance levels.
- Do not combine with other hormone protocols unless advised – Layering hormone treatments without timing management can derail ovulation patterns.
- Only administer after proper reproductive history is evaluated – Use in silent heat or postpartum animals must be customised based on condition and cycle stage.
- Avoid use during summer heat stress periods – Elevated temperatures may affect absorption and hormonal efficacy; plan usage accordingly.
How to store Clomiphene + Copper bolus?
- Avoid direct sunlight and fluorescent light exposure: Clomiphene is photosensitive. Even short-term UV exposure can degrade its molecular structure, reducing its ability to trigger ovulation in breeding programs.
- Maintain consistent temperature below 30°C—especially during transport or field storage: Fluctuations in heat can destabilise the hormonal compound, diminishing reproductive efficacy and risking uneven hormonal release.
- Label and store separately from other veterinary or human medicines: Accidental administration—especially to pregnant animals or the wrong species—can disrupt hormonal cycles or cause toxicity.
- Do not use if the bolus shows surface oxidation or packaging is compromised: This may indicate copper leaching or hormonal degradation, both of which can interfere with intended outcomes in fertility management.
Clomiphene + Copper bolus manufacturer and supplier in India
Estrus detection failures. Unpredictable AI (Artificial insemination) cycles. The bolus loses potency before it reaches the field.
Veterinary distributors know the problem isn’t just the product—it’s the timing. If your AI protocols fail during peak breeding season, you don’t just lose animal cycles—you lose farmer trust, market credibility, and long-term customers.
That’s why Therawin Formulations doesn’t treat this as just another bolus. With 35+ years of veterinary pharma experience, we manufacture and deliver Clomiphene + Copper Sulphate bolus solutions tailored to field realities:
- Hormonal integrity under pressure – Stable, copper-supported formulation built for long-distance rural distribution
- Batch-tested for real-time results – Every batch supports reliable estrus induction for cattle and buffaloes
- Franchise-ready availability – For distributors who need consistent stock during peak AI seasons
- PCD and private-label options – Expand your brand footprint with our proven formulation
- No stock-outs during critical cycles – Timed production schedules to match breeding demands
We don’t just deliver a bolus—we support reproductive timelines, help you retain high-value clients, and protect your market position.
Reach out for third-party pharma manufacturing, pharma PCD franchise partnerships, or AI-season readiness planning. Let’s bring predictability back to livestock reproduction—starting with better bolus availability.