Multi-pathogen skin infections don’t respond well to single-agent treatments. Steroids alone suppress inflammation but can worsen fungal infections. Antifungals kill fungi, but they leave bacterial superinfections untreated. That’s why dermatologists count on this four-in-one formulation—a balanced combination that guarantees infections are eliminated at all levels.
However, not all formulations achieve uniform absorption and stability. Clobetasol’s potency fluctuates in unstable bases. Ofloxacin and Ornidazole, insoluble in water, need precise emulsification to penetrate infectious layers properly. Itraconazole, for its poor skin permeability, needs micronised dispersion for clearances deep in the skin. Without precise formulation, these active ingredients degrade unevenly, leading to inconsistent therapeutic results.
That’s why Therawin Formulations, a WHO-GMP & ISO-certified manufacturer in India, optimises:
- Micronised antifungal delivery for sustained action
- Stable steroid-antibiotic balance to prevent bacterial overgrowth
- Advanced emulsification techniques for deeper penetration
As a leading Clobetasol + Ofloxacin + Ornidazole + Itraconazole cream manufacturer in India, Therawin Formulations offers:
- Pharma PCD franchise opportunities for regional distributors
- Third-party pharma manufacturing with custom branding & packaging
- Regulatory-compliant production ensuring safety & stability
Expand your dermatology range with a proven, high-demand formulation. Secure your pharma PCD franchise or third-party pharma manufacturing partnership with Therawin Formulations—where precision meets pharmaceutical excellence.
Generic name
Clobetasol + Ofloxacin + Ornidazole + Itraconazole
Pack
5 g / 10 g / 15g
Description
This four-in-one formula is indicated for troublesome, treatment-refractory skin infections where monotherapy is often inadequate.
- Clobetasol Propionate (Steroid) – (Severe Inflammation & Itching) Blunts skin inflammation, redness, and swelling of eczema, dermatitis, and resistant fungal infection.
- Ofloxacin (Antibiotic) – (Combats Secondary Bacterial Infections) Prevents bacterial superinfections that arise in damaged or untreated skin lesions.
- Ornidazole (Antiprotozoal) – (Treats Anaerobic Bacterial Infections) Targets deep-seated bacterial infections that antibiotics alone might not cure.
- Itraconazole (Antifungal) – (Extremely Potent Against Resistant Fungal Infections) More potent than fluconazole & ketoconazole in curing ringworm, athlete’s foot, and candida infections.
Mixed infections demand a multidimensional treatment—this combination therapy manages inflammation, prevents bacterial proliferation, and destroys fungal pathogens, making it a complete solution to chronic skin disorders.
Clobetasol + Ofloxacin + Ornidazole + Itraconazole cream uses
Twice a day or as prescribed by a doctor, apply a thin coating to the afflicted region. Avoid using on open wounds, broken skin, or mucous membranes—this will lead to excessive absorption or irritation. Avoid covering the area with tight bandages unless under the direction of a physician since it can increase corticosteroid absorption, posing a higher risk of skin thinning.
Use for the specified duration only—long-term use can result in steroid-induced side effects such as thinning of skin, discolouration, or delayed healing.
This combination is doctor-trusted for treating:
- Fungal infection complicated by bacterial infections
- Eczema & dermatitis with secondary infection aggravation
- Tinea (ringworm), athlete’s foot, and candidiasis
- Bacterial-fungal mixed skin conditions
Clobetasol + Ofloxacin + Ornidazole + Itraconazole cream side effects
While this cream is highly effective, side effects can occur if used improperly or for extended periods. Early identification of them and information regarding management or prevention can make treatment safer and more effective.
Common side effects (usually mild & manageable)
- Skin thinning or colour alteration: Long-term use of steroids weakens and thins or lightens the skin barrier. Use only for the length of time prescribed, and avoid using on sensitive areas like the face, groin, or armpits.
- Mild burning, redness, or inflammation: Apply a moisturiser after absorption and reduce frequency if inflammation develops.
- Temporary dryness or peeling: Antifungals and antibiotics can upset the skin’s natural balance. Steer clear of harsh soaps, scrubs, or alcohol-based cleansers while using the cream.
Serious side effects (require immediate medical attention)
- Severe allergic reaction (Swelling, rash, breathing difficulty): Stop using the cream at once and seek emergency medical attention.
- Worsening or spreading of infection: If symptoms spread outside the treated area, discontinue use and see a doctor to reevaluate treatment.
- Repeated burning, blistering, or pus formation: These can be signs of skin damage or secondary infection—discontinue use and seek a doctor.
How to store Clobetasol + Ofloxacin + Ornidazole + Itraconazole cream?
- Store at 15°C–30°C (Room Temperature): Corticosteroid breakdown caused by excessive heat reduces anti-inflammatory potency. Freezing can lead to separation of the base of the cream, leading to irregular application.
- Avoid Direct Sunlight: Light-sensitive components, particularly Clobetasol, may degrade with prolonged UV exposure, reducing effectiveness.
- Do Not Transfer to Another Container: The cream is formulated for specific pH and stability conditions inside its original packaging. Exposure to different materials may alter its consistency and effectiveness.
Clobetasol + Ofloxacin + Ornidazole + Itraconazole cream manufacturer and supplier in India
In dermatology, failure is not just a case of choosing the wrong product—failure is a matter of formulation variability, stability issues, and regulatory loopholes. That’s why leading PCD distributors & companies seeking third-party manufacturers rely on Therawin Formulations, a 35+ year-old pharmaceutical company with a history of combination dermatological treatments.
Why Therawin Formulations?
- WHO-GMP & ISO-certified manufacturing: Every batch is tested stringently for stability to ensure consistent strength across different climates and storage conditions.
- Precision-engineered steroid-antibiotic-antifungal balance: Prevents overuse complications, ensuring maximum absorption and efficacy for combined infections without increasing the risk of resistance.
- Long-term stability & retention of active pharmaceutical ingredients: Advanced micronisation and homogenisation prevent separation, loss of potency, or uneven distribution—key concerns in steroid-antifungal combinations.
- Custom branding & region-specific franchise associations: White labelling facilities allow distributors to sell under their own brand name, while pharma PCD franchise support ensures easy market entry.
Regardless of whether you need an established third-party manufacturer or wish to expand your portfolio within dermatology, Therawin Formulations offers expertise, compliance, and market-ready solutions.