Reduced weight gain, milk yield fluctuations, and reproductive issues. When livestock underperforms despite proper nutrition, the parasitic load is often the hidden culprit. Left unchecked, internal parasites not only compromise animal health but silently erode a farmer’s return on investment.
That’s where Ivermectin + Fenbendazole bolus delivers broad-spectrum, dual-action deworming in a single oral dose—targeting both roundworms and flatworms, including gastrointestinal, hepatic, and pulmonary species.
The combination enhances therapeutic reach in high-burden or previously dewormed animals where resistance or reinfection is a concern. Each bolus is developed with:
- Controlled disintegration to ensure consistent drug release and systemic distribution
- Formulation stability to maintain potency across varying field conditions
- Ruminant-specific absorption profile for optimised efficacy in cattle and buffalo
This bolus supports integrated parasite management strategies—reducing the parasitic load while aligning with the physiological demands of high-yield livestock.
Looking for an Ivermectin + Fenbendazole bolus manufacturer in India? Therawin Formulations offers veterinary pharmaceutical manufacturing through pharma PCD franchise and third-party pharma manufacturing partnerships, backed by WHO-GMP and ISO-compliant processes designed for consistency and clinical performance.
Generic name
Ivermectin 100 mg + Fenbendazole 3g
Description
This anthelmintic bolus delivers a dual-mode deworming effect by combining two well-established actives:
- Ivermectin 100 mg – a macrocyclic lactone with systemic activity
- Fenbendazole 3 g – a benzimidazole-class broad-spectrum anthelmintic
Together, they cover a wide spectrum of internal and external parasites in livestock, making the formulation suitable for strategic deworming in cattle and large ruminants.
Ivermectin binds to glutamate-gated chloride channels in parasites to disrupt neuronal signal transmission, which results in:
- Paralysis and death of adult and immature roundworms, lungworms, and ectoparasites such as mites, lice, and mange-causing organisms
- Disruption of parasite life cycles at both skin and gastrointestinal levels
Fenbendazole acts by inhibiting microtubule formation within intestinal helminths, affecting energy production and nutrient uptake.
Ivermectin + Fenbendazole bolus uses
This oral deworming bolus combines two broad-spectrum antiparasitic agents to eliminate internal and external parasites in livestock. It targets roundworms, lungworms, tapeworms, and mites—offering a comprehensive shield against mixed parasitic infestations.
Which parasites does it target?
- For cattle and buffaloes: Gastrointestinal worms, lungworms, and skin mites (like Sarcoptes). (Administer using a standard bolus applicator. Ensure the animal hasn’t been recently fed—a full stomach may reduce absorption. Bolus should be placed deep in the throat to avoid spitting or partial chewing.)
- For sheep and goats: Stomach worms, threadworms, and tapeworms. (Use a small-ruminant applicator to prevent injury or rejection. Never crush the bolus into feed—Fenbendazole has a bitter profile, and rejection is common. Dosing should be based on weight—partial bolus may be needed for lightweight animals.)
- For camels and large ruminants: Mixed helminth infestations including Haemonchus, Trichuris, and mange mites. (Always restrain camels gently—administer during cooler parts of the day to avoid stress-induced regurgitation. Administer with clean, gloved hands to avoid contaminating the bolus.)
Do not use in poultry, dogs, or cats. This bolus is formulated specifically for large and medium-sized ruminants. Dosing outside the recommended species can lead to toxicity or treatment failure.
Use under veterinary guidance, especially in herds showing resistance to single-agent dewormers or during rotational deworming cycles. Avoid use in late-pregnant animals unless clearly advised by a vet.
Ivermectin + Fenbendazole bolus side effects
This combination bolus is extensively used to remove both internal parasites (nematodes, flukes) and external infestations (mites, lice) in animals. Although highly effective, improper use, dosing, or animal sensitivities can induce adverse effects.
Mild & temporary reactions
(Common and usually resolved without intervention)
- Loose stools or mild diarrhea – Parasite die-off can temporarily irritate the gut lining. Maintain hydration and prevent concomitant feed changes while administering.
- Lethargy or drowsiness – Transiently the nervous activity in young or lightweight animals can be suppressed by ivermectin. Allow rest and watch for 24 hours.
- Depressed appetite – Fenbendazole can somewhat suppress appetite in the process of expelling the worms. Allow fresh, high-energy feed following treatment to recover.
Rare & serious side effects
(Require immediate veterinary care)
- Neurological signs – Ivermectin, when overdosed or administered in sensitive individuals (such as young calves, and exotic animals), can cause ataxia, tremors, or even coma. This is due to its GABA-mediated effects on the central nervous system.
- Allergic shock – Acute respiratory distress, swelling, or collapse can be signs of hypersensitivity, particularly in genetically predisposed animals. Immediate vet response is essential.
- Liver overload or toxicity – High levels or multiple treatments with no interval can strain hepatic function. Clinical signs are jaundice, disorientation, or anorexia.
Common mistakes to avoid:
- Do not administer to pregnant animals in early gestation (first 45 days) – Ivermectin has been found to have embryotoxicity during early fetal development.
- Do not use concurrently with other CNS depressants or wormers – Synergistic toxicity can be produced, particularly in goats or sensitive breeds of cattle.
- Provide precise weight-based dosing – Underdosing raises resistance risk; overdosing raises toxicity.
How to store Ivermectin + Fenbendazole bolus?
- Never store near livestock feed or mineral blocks: Ivermectin is highly potent, even in trace amounts. Cross-contamination from exposed bolus can accidentally medicate non-target animals or disrupt dosing schedules—especially in mixed-species farms.
- Keep tightly sealed in original blister packs: Fenbendazole degrades gradually when exposed to oxygen and moisture. Once opened, the bolus may lose its uniformity, resulting in underdosing or inconsistent parasite clearance.
- Avoid storage in hot, poorly ventilated barns or metal cabinets: Ivermectin is sensitive to thermal degradation. At sustained temperatures above 30°C, its antiparasitic efficacy drops—posing a risk of treatment failure, especially for stubborn worm infestations.
Ivermectin + Fenbendazole bolus manufacturer and supplier in India
In regions facing parasite resistance to standalone dewormers, a dual-acting bolus isn’t optional—it’s essential. Many formulations on the market fail to account for field-use factors like uneven bioavailability, rumen pH interference, or climate-induced instability.
At Therawin Formulations, we manufacture clinically balanced Ivermectin + Fenbendazole bolus that meets the practical needs of today’s veterinary suppliers and livestock dealers.
Backed by 35+ years in veterinary pharmaceutical development, we support:
- Consistent efficacy in mixed helminth infestations – Effective against GI roundworms, lungworms, and adult liver flukes
- Formulation engineered for ruminal release – Avoiding premature breakdown or underdosing in large ruminants
- Longer shelf life, stability-tested – For stockists working in hot and humid supply zones
- PCD & third-party supply support – Covering pan-India veterinary franchise networks
- Export-grade packaging & custom branding – Designed for animal health brands expanding into new regions
Whether you’re addressing seasonal mass deworming needs, stocking up for pasture-rearing farms, or managing multi-veterinarian procurement contracts, our bolus offers repeatable results and field-proven performance—without compromising on compliance.
Available in flexible packs and custom strengths. Connect with Therawin for samples, private-label third-party pharma manufacturing, or pharma PCD franchise distribution setup.